Somatic recombination in the IGH gene of B cells is used to make cell-specific immunoglobulin heavy chains.

-

Somatic recombination in the IGH gene of B cells is used to make cell-specific immunoglobulin heavy chains.




The human IGH gene has multiple but slightly different repeats for each of four types of gene segments: V (first part of variable region), D (diversity region), J (joining region), and C (constant region; each of the C gene segments has a coding sequence split by introns). An immunoglobulin heavy chain is made by bringing together coding sequences from one each of these four types of segments (shown here as filled boxes). Two sequential somatic recombinations produce first D-J joining, then a mature, functional VDJ coding sequence unit, which is effectively a large novel exon. Another type of somatic recombination (known as class switching can change the position of C gene segments so that other C gene segments can be used instead of Cμ to give alternative classes of immunoglobulin.

Comments

Post a Comment

Popular posts from this blog

Discuss the seven characteristics of useful information.

-
Discuss the seven characteristics of useful information. Answer: The seven characteristics of useful information are: relevant, reliable, complete, timely, understandable, verifiable and accessible. These characteristics are qualities that information should possess to be useful in a business environment. Briefly stated, in order for information to be useful it must be: 1) relevant, meaning that it reduces uncertainty and adds to the decision-making process; 2) reliable information is information that is free from error, and is accurate in its nature; 3) complete information is information that does not omit any important data, facts, or aspects about events or activities; 4) information is timely when it is fully available to enable the decision-making process to proceed; 5) understandable information must be both in an intelligible and useful format; 6) information is considered verifiable if two people, acting independently of each other, produce the same inform
Read more

Why have accounting software packages been designed with separate transaction modules?

-
Why have accounting software packages been designed with separate transaction modules? Answer: : Since every organization does not necessarily use all of the transaction cycles in its operations, it is to the advantage of the organization to be able to "pick and choose" from among various software modules that track and record different transaction cycles. For example, a law firm would have no need to implement a production cycle module. Also, the nature of a transaction cycle varies across the broad spectrum of business organizations. Again, a law firm would have a revenue cycle, but it would not involve the purchase, receipt, and payment for products or merchandise; likewise a retail store chain may not sell any consulting services to its customers.
Read more

A laboratory assistant prepared solution of 0.8 M, 0.6 M, 0.4 M, and 0.2 M sucrose, but forgot to label them. After realizing the error, the assistant randomly labeled the flasks containing these four unknown solutions as flask A, flask B, flask C, and flask D.

-
A laboratory assistant prepared solution of 0.8 M, 0.6 M, 0.4 M, and 0.2 M sucrose, but forgot to label them. After realizing the error, the assistant randomly labeled the flasks containing these four unknown solutions as flask A, flask B, flask C, and flask D. Design an experiment, based on the principles of diffusion and osmosis, that the assistant could use to determine which of the flasks contains each of the four unknown solutions. Include in your answer (a) a description of how you would set up and perform the experiment: (b) the results you would expect from your experiments: and (c) an explanation of those results based on the principles involved. (Be sure to clearly state the principles addressed in your discussion.)
Read more