If you can't or won't wait the entire lag between the youngest and oldest ages in which you're interested?

If you can't or won't wait the entire lag between the youngest and oldest ages in which you're interested?



Answer: You can run a staggered hybrid design, instead. This design has lots of smaller lags embedded inside it, but with many overlapping specific ages, so that you can conduct lots of double-hybrid-like tests. If all of these tests show no evidence of cohort or time-frame effects, then you can safely compare the "youngest" data to the "oldest" data to get the desired difference. In this way, you can compare, for example, 30 year-olds to 55 year-olds in a study that only takes 5 years to run and has "defenses" against the two main threats to aging research.

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