What happens to a denatured enzyme regarding its functionality? How can that result be explained with the help of the lock and key model?

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What happens to a denatured enzyme regarding its functionality? How can that result be explained with the help of the lock and key model?



According to the lock and key model the enzyme functionality depends entirely on the integrity of the activation center, a molecular region with specific spatial characteristics. After the denaturation the spatial conformation of the protein is modified, the activation center is destroyed and the enzyme loses its catalytic activity.

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