What happens when DNA coils around histones/ 8 nucleosomes, and what does tightening and loosening of this coil mean?

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What happens when DNA coils around histones/ 8 nucleosomes, and what does tightening and loosening of this coil mean?




In interphase, the chromatin fiber is organized in looped domains, each containing about 50-200 kilobases of DNA, that are attached to a central scaffold of non-histone proteins. High levels of gene expression require local uncoiling of the chromatin fiber to give the 10 nm nucleosomal filaments. The diagram does not show structural RNAs that can be important in chromatin.

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