Explain the fidelity of DNA polymerase.

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Explain the fidelity of DNA polymerase.




The classical DNA-dependent DNA polymerases are high-fidelity polymerases—they insert the correct base with high accuracy; however, we also have many non-classical DNA-dependent DNA polymerases that exhibit comparatively low fidelity of DNA replication but have roles in certain types of DNA repair and in maximizing the variability of immunoglobulins and T-cell receptors.

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