Describe mitochondrial DNA (mtDNA) replication?

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Describe mitochondrial DNA (mtDNA) replication?




Instead of two copies, mitochondrial DNA (mtDNA) replication is stochastic. When a mitochondrion increases in mass in preparation for cell division, the overall amount of mitochondrial DNA increases in proportion, but individual mtDNAs replicate unequally. Variants of mtDNA can arise through mutation so that a person can inherit a mixed population of mtDNAs (heteroplasmy). Unequal replication of pathogenic and nonpathogenic mtDNA variants can have important consequences.

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