If you can't or won't wait the entire lag between the youngest and oldest ages in which you're interested?

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If you can't or won't wait the entire lag between the youngest and oldest ages in which you're interested?



Answer: You can run a staggered hybrid design, instead. This design has lots of smaller lags embedded inside it, but with many overlapping specific ages, so that you can conduct lots of double-hybrid-like tests. If all of these tests show no evidence of cohort or time-frame effects, then you can safely compare the "youngest" data to the "oldest" data to get the desired difference. In this way, you can compare, for example, 30 year-olds to 55 year-olds in a study that only takes 5 years to run and has "defenses" against the two main threats to aging research.

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